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Oxford University Press is a department of the University of Oxford. It furthers the University's objective of excellence in research, scholarship, and education by publishing worldwide. Sign In or Create an Account. Sign In. Advanced Search. Search Menu. Article Navigation. Close mobile search navigation Article Navigation. Volume Article Contents Abstract. Materials and methods. Results and discussion. Contribution of catalase to hydrogen peroxide resistance in Enterococcus faecalis. Michael Baureder , Michael Baureder.
Oxford Academic. Ronny Reimann. Lars Hederstedt. Revision received:. Select Format Select format. Permissions Icon Permissions. Abstract Enterococcus faecalis exhibits high resistance to oxidative stress. Open in new tab. Open in new tab Download slide. Overcoming the heme paradox: heme toxicity and tolerance in bacterial pathogens.
Google Scholar Crossref. Search ADS. Glycerol is metabolized in a complex and strain-dependent manner in Enterococcus faecalis. Induced cell aggregation and mating in Streptococcus faecalis : evidence for a bacterial sex pheromone.
The presence of doxycycline led to decreased growth for all of the new C. No significant effect of doxycycline on growth and fitness was observed for the old C. This correlated with a reduction in catalase levels in these isolates over time Fig S4A. These data indicate that the old isolates 4 and 10 had indeed lost their in vitro fitness defect over time, thereby explaining their lack of phenotype in vivo. The growth of new C. Conceptualization: AJPB. Software: AR. Supervision: AJPB. Writing — original draft: AJPB.
Abstract Most fungal pathogens of humans display robust protective oxidative stress responses that contribute to their pathogenicity. Author summary The pathogenic yeast Candida albicans faces multiple challenges within its human host. Introduction Of the circa three million fungal species that are thought to inhabit our planet [ 1 ], only a relatively small number have been reported to cause infections in humans.
Download: PPT. Fig 1. Manipulation of catalase levels in C. Fig 2. Elevated basal levels of catalase protect against oxidative and combinatorial stresses. Oxidative stress resistance and catalase levels in clinical isolates C.
Fig 3. Basal catalase expression and oxidative stress resistance in C. Population heterogeneity promotes C. Fig 4. Stochastic differences in catalase expression within a population of C.
Impact of catalase levels on host colonisation during systemic infection We tested whether high basal catalase levels affect the ability of C.
Fig 5. Impact of catalase levels on host colonisation during systemic infection. Fig 6. Inactivation of catalase does not attenuate C. Catalase promotes resistance to neutrophil killing It has been reported that catalase null mutants do not display significantly higher sensitivities to neutrophil killing [ 5 ]. Fig 7. Impact of catalase on resistance to neutrophil killing. Elevated catalase levels affect the ability of C.
Fig 8. Impact of catalase levels upon C. Ectopic catalase expression confers a fitness defect in the absence of stress that is suppressed by iron supplementation Doxycycline-treated C. Fig 9. In the absence of stress, elevated catalase levels impose a fitness defect on C. Discussion This study has important implications for the impact of the key peroxide detoxifying enzyme, catalase, upon the stress resistance and virulence of the major fungal pathogen, C.
Materials and methods Strains, growth conditions and treatments The strains used in this study are listed in S1 Table. Barcode sequencing To quantify the relative concentration of each barcoded strain in mixed populations of tetON strains, genomic DNA was prepared from the populations by phenol: chloroform extraction method [ 66 ].
Transcript levels RNA was extracted from C. Catalase assays C. Virulence assays The virulence of C. Supporting information. S1 Fig. Stress resistance of C. S2 Fig. Gating strategy for the analysis of C.
S3 Fig. Analysis of C. S4 Fig. S5 Fig. S1 Table. Strains used in this study. S2 Table. Primers used in this study. S3 Table. Barcodes used in this study. References 1. Hawksworth DL. Global species numbers of fungi: are tropical studies and molecular approaches contributing to a more robust estimate?
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